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It's interesting to note that lung cancers do not express glutamine synthetase (GS), which catalyzes the synthesis of glutamine from glutamate and ammonia [44]

We then performed a gene set enrichment analysis (GSEA) to determine the association between the expression of ACTL6A and signaling pathways in the RNA array results, which indicated significant differences between ACTL6A-KD cells and control cells in multiple metabolism-related pathways, among which GSH metabolism ranked as one of the most highly correlated pathways (Fig

Morales JK, Falanga YT, Depcrynski A, Fernando J, Ryan JJ

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The Pernicious Anaemia Society notes this is well recognised but not fully understood