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Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis

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Vitamin E acts as a regulator of cellular metabolism, and its deficiency leads to anaemia, dysregulation of energy metabolism, irregular mitochondrial function, and tissue damage resulting from increased lipid peroxidation (170)

doi:10.3390/antiox9111070

When compared to experimental and clinical data on the accumulation of the byproducts of acetaminophen metabolism, APAP-S, APAP-G, and NAPQI-GSH, in the plasma and in the urine of humans, the model gives accurate predictions (see Figures2,3,4 and5)