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Here we report high-resolution cryo-electron microscopy (cryo-EM) structures of human GLP-1RG s in complex with compound 2 alone, with both compound 2 and endogenous peptidic agonist GLP-1, or with compound 2 and a small molecule agonist (LY3502970)

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The results were striking: women taking GLP-1s showed a 72% improvement in natural pregnancy rates (RR: 1.72, 95% CI 1.22-2.43), meaning they were 1.72 times more likely to conceive naturally compared to the control group