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It slows digestion, increases fullness, and curbs cravings, naturally lowering calorie intake

PMID: 22123752, PMCID: PMC3688066, DOI: 10.1001/archinternmed.2011.569

Despite this, the initial clinical results show promise, particularly the TRIUMPH-1 Phase 3 trial, which demonstrated an average weight loss of up to 28.3% over 80 weeks

An aminoisobutyric acid (Aib) substitution at position 8 protects against degradation by dipeptidyl peptidase-4 (DPP-4), while attachment of a C18 fatty diacid chain via a -glutamic acid spacer promotes strong binding to serum albumin

The initiative is set to launch in April for Medicaid and January 2027 for Medicare plans