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GLP-1 drugs act in a variety of ways that account for their successfulness in weight loss and the management of blood sugar levels: 1

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The first week at 10 mg often brings renewed side effects, following the familiar pattern

They described their safety profiles as generally favorable, with mostly mild gastrointestinal adverse effects. The supportive evidence is largely limited at this time to patients who are already candidates for GLP-1 RAs, such as those with obesity, diabetes, and cardiovascular risk factors driven by metabolic comorbidities