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Effective pharmacotherapy for obesity is likely to require long-term, if not life-long, treatment, which makes it important to consider long-term adherence and weight loss efficacy, and the effects on obesity co-morbidities (particularly cardiovascular outcomes), safety (including potential adverse effects on muscle mass and bone health), and cost of poly-agonist therapy

Finally, the fact that normal ducts, ductal pancreatic carcinomas, or PanIN 3 do not express GLP1R indicate that GLP1Rs are unlikely to be related to neoplastic transformation in the pancreas

It had demonstrated that the degeneration of the diabetic condition could be reversed, even that the disease itself could be put into a drug-free remission with continuous remote care and a diet that restricted carbohydrates and replaced those calories mostly with fat

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