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In a direct head-to-head comparison, tirzepatide demonstrated similar benefits in reducing MACE as semaglutide

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The phenomenon of improvement of symptoms and change of microbiome was also found in another trial, the results of this study showed that the clinical symptoms of patients in both groups improved significantly after treatment, and the numbers of Enterobacteriaceae and Enterococcus were lower than before treatment, and the numbers of Lactobacillus and Bifidobacterium microbiome were higher than before treatment (38)