In a substudy of 178 patients from the SUSTAIN 8 trial on semaglutide as a diabetes treatment, the average proportion of lean mass loss was nearly identical at 40%, despite lower doses and less total weight loss than in the STEP 1 trial
Stimulation of biosynthesis of proteoglycans
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Classical Wnt signaling involves the interaction of lipid-modified Wnt, through a series of biochemical reactions, resulting in elevated nuclear -catenin levels, ultimately activating Wnt-mediated signaling (Schmiege and Li, 2024)
Given that semaglutide can alter gut microbiome composition, probiotic supplementation may provide additional protection