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Mechanistic Evidence of Pathophysiologic Target Besides the development of various efficient DPP-4 inhibitors and the demonstration that they have glucose-lowering properties, an important factor behind the concept of DPP-4 inhibition was that it targets the basic pathophysiological processes in type 2 diabetes

Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes

its rise signals that the liver is shifting toward fat burning

Both are well-studied individually in preclinical models