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Beyond serving as a reducing cofactor for antioxidant enzymes, GSH exerts direct antioxidant activity by scavenging reactive oxygen species (ROS) and RNS, including superoxide anions (O 2 ), H 2 O 2 , and hydroxyl radicals (OH) 3

Li G, Yu C, Yu P, Peng Q, Wang Q, Ren S, et al

Specifically, simulations suggest that blood Cys and GSH are reduced by 68.7% and 74.1% respectively, whereas cytosolic Cys and GSH are reduced by 81.2% and 64.6% respectively

Rather, beneficial cellular functions can be derived from preservation of cell signaling functions through maintenance of the extracellular GSH and thiol redox balance

The individuals overall health status and specific concerns will also play a role in determining whether glutathione IV therapy is an appropriate choice