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Neuroprotection Preclinical research suggests GLP-2 (T) mitigates amyloid-beta plaque formation, slows cognitive decline, and promotes neuronal survival, offering potential benefits in Alzheimers disease ( 6 )

Extensive human data has not confirmed the rodent findings translate to people

Brand-name GLP-1 prescriptions are sent to your local pharmacy

10.3389/fnut.2025.1527207 83 HendrickxG.BorraV

Mechanistic studies further propose that increased intestinal permeability (leaky gut) may allow bacterial metabolites and endotoxinssuch as lipopolysaccharideto enter the circulation and activate systemic and neuroinflammatory pathways ( In a Chd8 deficient mouse model, excessive epithelial proliferation and microvillus abnormalities were linked to BBB dysfunction and microglial activation