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Severe cases may lead to splenomegaly Splenomegaly Splenomegaly is pathologic enlargement of the spleen that is attributable to numerous causes, including infections, hemoglobinopathies, infiltrative processes, and outflow obstruction of the portal vein
Alternatively, null results across trials might indicate that current supplementation strategies are inadequate to achieve cardiovascular benefits, either due to insufficient dosing, inappropriate target populations, or suboptimal timing of the intervention