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Investment in, and new thinking on, Real World Evidence programmes for Obesity research: Real world data will be critical to understand the real, long-term value of the use of obesity agents, because it is clear that there is a highly diverse patient body, and social determinants of health are increasingly recognised as a crucial element in obesity research, because the role of the patient themselves in driving treatment outcomes is critical, especially when the patient pays for the obesity treatment out of pocket, and because of the importance that new digital technologies can have in collecting a broader range of data, including patient reported outcomes 16
This multi-receptor approach distinguishes retatrutide from earlier agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1 and GIP receptor agonist)
89 Moreover, studies have shown that they strengthen the intestinal barrier and reduce gut permeability and, by that, exhibit anti-inflammatory effects that are an important component in NASH development
It was also shown to have positive outcomes in a cardiovascular outcomes trial [22]
