BRB disruption is a primary pathogenic mechanism of DR and the key factor driving DR progression from non-proliferative DR (NPDR) to proliferative DR (PDR)
I started taking NAC and the headache went away, but the NAC caused constipation since Glutathione isnt well-absorbed taken orally, I figured out that a patch would be a good solution since I read that it is used intraveniously to help people heal after surgery and also that NAC is the only thing that helps if someone has acetaminafen liver toxicity So I started the Glutathione patch and the headaches have not come back for several months
Importantly, brain endothelial cells are known to gain their specialized BBB functions through interactions with other cells of NVU such as pericytes, astrocytes, and neurons ( The decline of BBB and BCB are involved in many neurological diseases (Zenaro et al., 2017) and Parkinsons disease (Oby and Janigro, 2006), etc
In human patients, glutathione has been used as a treatment for chronic liver disease, mostly by intravenous administration
Chang Y, Wei W, Zhang L, Xu HM
