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(38) reported microglia and astrocytes overactivation, increase in proinflammatory cytokines, mitochondrial dysfunction, and abnormal neuronal morphology in the hippocampus of young and old mice subjected to 24 h of sleep deprivation, whereas treatment with urolithin A protected against these adverse effects

The CLCN5 gene is located on the X chromosome (Xp11.23) and is composed of 17 exons that generate five alternatively spliced mRNAs that collectively encode four different protein isoforms