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112 While H 2 S-mediated protein per-sulphidation is relevant in any cellular compartment, mitochondrial H2S generation is particularly relevant for cellular bioenergetics, as detailed later in the article

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Adjunctive topical agents may be applied during treatment depending on clinical judgement

This means it may raise plasma levels of drugs with a narrow therapeutic index, including ciclosporin, tacrolimus, certain direct oral anticoagulants (DOACs), and digoxin