The TRIUMPH program is testing exactly this question with a 4mg maintenance arm
Nausea is the most frequently reported issue, especially with the first few doses, but often decreases with continued use or with dose adjustments
Oral BPC-157 can be useful for gut mucosal support, but it should be paired with attention to food triggers, alcohol intake, NSAID use, stress physiology, microbiome health, sleep, and appropriate GI evaluation when symptoms warrant it
It can indicate bacterial contamination, that the powder hasnt fully dissolved, or a problem with the diluent
In a third trial, liraglutide significantly reduced weight by 8 pounds relative to placebo over 10 months in stable patients with bipolar disorder regardless of whether they were taking an antipsychotic (McElroy SL et al, J Clin Psychopharm 2024;44(2):8995)