For people with genetic predispositions toward higher appetite drive (such as variants in the GLP1R or MC4R genes), this rebound can feel especially intense because their baseline hunger regulation is naturally more aggressive
PMID: 66 AnaclerioFPilenziLDellEliceAFerranteRGrossiSFerlitoLMet al
Xie Z, Zhou G, Zhang M, Han J, Wang Y, Li X, et al
In the Pancreas In the pancreas, GLP-1 receptors help regulate blood sugar by stimulating insulin release when glucose levels rise after eating
We also examined the possibility of surveillance bias, where GLP-1 RA users could have had more encounters, leading to faster diagnoses of cirrhosis and complications, and found no evidence of this