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S., Schell, T
[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Altomare A., Di Rosa C., Imperia E., Emerenziani S., Cicala M., Guarino M.P.L
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Upon oxidative stress, Keap1 is inactivated, allowing Nrf2 to translocate into the nucleus, where it upregulates downstream antioxidant genes such as HO-1 and NQO1, thereby restoring redox balance ( Although our research has demonstrated that AST has the ability to restore Nrf2 nuclear translocation and upregulate the expression of HO-1/NQO1, the causal role of Nrf2 has not yet been directly verified through gene silencing techniques, which represents a key limitation
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