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The functioning of the pituitary gland and the hormones it secretes decreases with aging, however, IGF-1 is capable of bypassing the pituitary gland and is able to elicit the same response as GH does

It was among the first synthetic GHSRPs to be characterised in detail and remains a reference compound in growth hormone axis research

Typical cycles range from 4-6 weeks under medical supervision, followed by an off period to maintain receptor sensitivity

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It is structurally modified from native human IGF-1 through two primary alterations: an arginine substitution at position 3 and the addition of a 13amino acid extension at the N-terminus