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John Winkelman used to refer to restless legs syndrome (RLS) as the Rodney Dangerfield of medicine - since, as the late comedian famously claimed about himself, the disorder "got no respect." Long after RLS was first described in the 17th century, the creepy-crawly, sometimes painful leg sensations characterizing it - which are typically worse while resting - were often dismissed as a bizarre neurosis

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[2] [3] Research indicates that GHK-Cu may increase synthesis of collagen, elastin, and glycosaminoglycans