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MT, a hormone secreted by the pineal gland, possesses strong neuroendocrine immunomodulatory properties and free radical scavenging abilities

In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

Unlike a prior meta-analysis, 11 we modeled with HDRS, BDI, and MADRS separately rather than prioritizing a single scale

It is not approved for human or veterinary use and no therapeutic claims are made

Proteins expressed in bacterial cells may be present in insoluble inclusion bodies