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Both medications commonly cause mild gastrointestinal effects such as nausea, reduced appetite, and occasional vomiting during dose escalation, typically diminishing over weeks

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This cascade leads to neuronal apoptosis and energy deficits, particularly in the prefrontal cortex and hippocampus ( 4.3 Excitotoxicity Synthetic cathinones disrupt glutamatergic signaling by enhancing glutamate release and impairing astrocytic uptake (Zhang and Bhavnani, 2006)