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Cyanocobalamin, vitamin B12 preparations containing benzyl alcohol should be avoided in premature neonates because benzyl alcohol has been associated with gasping syndrome, a potentially fatal condition characterized by metabolic acidosis and CNS, respiratory, circulatory, and renal dysfunction

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Of equal concern is the fact that unregulated peptides may be contaminated with impurities, according to the FDA

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Funding This work was supported by a grant from MEXT KAKENHI (18K19670 to TA)