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24 Moreover, in CCS with a MET alteration, crizotinib has shown similar efficacy as doxorubicin-based chemotherapy

This result contrasts a recent study that found no evidence of differences in macrovascular disease prevention for GLP-1RAs compared with metformin in individuals with type 2 diabetes (whose hepatic steatosis status was unclear) [39]

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This mechanism is called the carnitine shuttle, in which fatty acids cross the mitochondrial membranes bound to L-carnitine, forming acylcarnitine molecules that can cross the mitochondrial membrane through a transporter in exchange for free L-carnitine

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