Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2) is an oligopeptide drug, orally active and blood-brain barrier-permeable angiotensin IV analog, binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor c-Met
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The induced reduction in the lactate/pyruvate ratio in healthy human volunteers during exercise suggests that naftidrofuryl increases the efficiency of aerobic metabolism in oxygen-deprived tissues [133]
