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Whereas the first incretin agonists targeted just GLP-1, both GLP-1 and GIP are the active targets of some of the new dual agonists such as tirzepatide

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Some people may see effects on their appetite as soon as 1 week after their first dose

108 The protein kinase RNA-like ER kinase (PERK), eukaryotic translation initiation factor 2 (eIF2), glucose regulatory protein (GRP78), and growth arrest and DNA damage 153 (GADD153/CHOP) are all endoplasmic reticulum stress-related proteins