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Yes, chills and temperature dysregulation can occur with semaglutide, though they are not among the most commonly reported side effects

Deionised water was used throughout the experiments to prepare the modified Tyrodes solution

Marques JM, et al

Retatrutide is an investigational peptide drug developed by Eli Lilly that acts as a triple agonist, simultaneously targeting three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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