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Some patients carry genetic variants associated with reduced GLP-1 receptor sensitivity, meaning they achieve superior results with higher tirzepatide doses or dual-compound protocols

When semaglutide is used for weight loss then the brand Wegovy is prescribed which is licensed for use by non-diabetic patients

Similarly, losing weight can lead to improvements in blood pressure, cholesterol and sleep apnea

When CAF S1 increases in the stroma, these cells can induce the recruitment and proliferation of CD25 + FOXP3 + T cells (Tregs), leading to the formation of an immunosuppressive TME [50]

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