ema glp-1 vision loss recommendation 2025 Eye Condition a 'Very Rare' Side Effect of Semaglutide, Says GLP-1 Drugs and Ocular Disease:

While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions

Accessed April 29, 2026

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Cochrane Database Syst Rev 2009;2:CD006142.Article 94

The following table summarizes the evidence landscape honestly, tier by tier