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LL-37 possesses immunomodulatory properties that influence various immune cells, including neutrophils, macrophages, dendritic cells, and lymphocytes (Nagaoka et al., 2001)

That is the single most useful framing for this question, so the rest of the guide is organized around it

Response: We do not agree that a separate regulatory impact analysis or additional study is necessary

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As such, this review highlights the urgent need for clinical trials targeting antiangiogenic therapies in neurodegenerative diseases, because without robust data from clinical studies, the efficacy and safety of such interventions remain speculative