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The liver responds to GH by producing IGF-1 , and IGF-1 is what actually drives the downstream tissue effects clinicians associate with growth hormone protein synthesis, satellite-cell activation for muscle repair, lipolysis, collagen synthesis, and bone remodeling

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A (Yael Horwitz, Clinical Programs Manager at Cylinder): In Cylinders Harris Poll, 86% of GLP-1 users reported GI symptoms like nausea, constipation, diarrhea, or abdominal pain

Still, there is a small percentage of people who have a vitamin B12 deficiency even before they undergo weight loss surgery

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