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The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior

The landmark trial for tirzepatide was SURMOUNT-1

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BPC-157

However, in MASH with significant fibrosis ( F2), pharmacological therapy provides measurable clinical benefits and should be considered with priority, especially if obesity or T2DM coexist (Fig