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Despite its benefits, a long-term KD may lead to several adverse effects, such as impaired glycaemic control (including reduced glucose tolerance), an adverse atherogenic lipoprotein shift (e.g., elevated apolipoprotein B levels), increased systemic inflammatory burden (e.g., higher C-reactive protein levels), and persistent restructuring of the gut microbiome (altered diversity) 199

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Cancer 9 , e001701 (2021)