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No adverse events associated with LC administration were recorded at a dose 6 g/day for 12 months of supplementation in the patients with acute anterior myocardial infarction [87], or at a dose 1.274 g/day (range 0.33 g/day) and duration 348 days (range 93744 days) in patients with liver cirrhosis [88]

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Similarly, CUR inhibits CYP3A4 and induces P-gp, altering the bioavailability of calcium channel blockers (e.g., amlodipine) and beta-blockers (e.g., carvedilol) (80)