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"Before we had no way of predicting who would benefit from therapies

Retatrutide has Phase 2 (Jastreboff et al., NEJM 2023, PMID 37366315) and Phase 3 (TRIUMPH-4, Bays et al., NEJM 2025, PMID 41090431) data

Clinical researchers observed that participants on the highest Retatrutide dose lost nearly 10 percentage points more body weight compared to those on the leading GLP-1 only medication

Based on the mechanism and available evidence, most experts expect acceptable long-term safety, but this remains an area where caution is warranted

Contrave : Seizures: Bupropion, one of the ingredients in Contrave , lowers the seizure threshold, increasing the risk in those prone to seizures