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joint involvement with characteristic pain/swelling/erythema, presence of any tophi or systemic symptoms History, e.g
A commonly used protocol involves administration five times per week for approximately eight weeks, followed by a two-week break before repeating the cycle, if appropriate
It might cause a bit of discomfort, but its typically not painful
In a model mimicking severe nephritis, which is essentially 100 percent lethal to the kidneys in humans and deadly to the mouse model, with treatment there was instead an 80 percent survival of the mice
This is very important during pregnancy
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