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Additionally, AESN has been reported to activate INS-1 cells under high-glucose conditions (117), with the underlying mechanisms illustrated in Figure 2

Secondary bile acids (lithocholic acid and deoxycholic acid) are its most potent agonists ( In the intestine, TGR5 activates enteroendocrine L cells, stimulating glucagon-like peptide-1 (GLP-1) secretion ( 3.3.2 Metabolic regulatory functions of short-chain fatty acids (SCFAs) As the primary fermentation products of dietary fiber, SCFAs serve as core mediators of communication between gut microbiota and host metabolism

It may help manage profound fatigue, brain fog, and exercise intolerance in Long COVID and ME/CFS

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Glutathione binds to fat-soluble toxins and helps convert them into water-soluble compounds that can be safely eliminated