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For the IL-17A/IL-22 fusion, significant protein engineering was required to obtain a dual activity profile in in vitro assays and to limit the peptide degradation during production, a phenomenon frequently observed for peptide fusion molecules expressed in transfected cells 30

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GLUT4: Glucose Transporter Type 4

USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3

Conclusive evidence of its efficacy and safety in humans requires additional clinical trials