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It is an area of investigation, not a proven healthy aging drug

Hurst, R., Bao, Y., Jemth, P., Mannervik, B

A review of the medical examination data from 25 autistic children found that 53% of these patients had increased pyruvate levels, 76% had elevated blood lactate, in 20% of them the lactate/pyruvate ratio in fibroblasts was increased, and 42% were presented with atypical results of urine organic acid analysis [72]

Although historically used as an antihypertensive agent, clonidine is now primarily reserved for resistant hypertension and selected hypertensive emergencies

Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer