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Overall, these results demonstrated that liraglutide induced broad anti-inflammatory dose-dependent effects in IL-1-stimulated murine chondrocytes

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The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]