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Indeed, the results of that screening revealed that impaired maternal folate metabolism could be of relevance for the birth of a DS child at advanced maternal age (Hollis et al., 2013)

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Figure 1 Culturing in Ringer Solution at Low Hematocrit Increases the Baseline Levels of PS Exposure and Hemolysis in Erythrocytes To test the influence of specific culture conditions on baseline levels of eryptosis, and in the absence of any drug, nave erythrocytes were incubated in either Ringer solution (at 0.4 or 4% hematocrit) or in cRPMI at 4% hematocrit ( Figures 2A, B )

A similar study by Kern et al