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Iron imunomodulates the termination of the inflammatory response, as elevated Fe level increase the M2 phenotype and reduce the pro-inflammatory M1 response, reducing the IL-12/IL-10 balance

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Sepsis: A small RCT in patients with sepsis found that IV NAC (150 mg/kg bolus then 50 mg/kg over 4 hours) improved hepatosplanchnic perfusion, glutathione levels, and liver function markers

Additionally, GLP-1RAs facilitate the maintenance of endothelial barrier integrity, thus playing a crucial role in preventing vascular leakage