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Smoking: Smoking is identified as a significant risk factor for TAO development (81)

B vitamins are essential for converting the carbohydrates, fats, and proteins you eat into actual usable energy

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The pathway of PDHc-mediated oxidation of pyruvate to acetyl-CoA is diagrammed below: The PDHc is comprised of multiple copies of three distinct enzyme activities: pyruvate dehydrogenase (PDH, identified as the E1 component), dihydrolipoamide S-acetyltransferase, (DLAT, identified as the E2 component), and dihydrolipoamide dehydrogenase, (DLD, identified as the E3 component)

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