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Ozempic (semaglutide), a GLP-1 receptor agonist manufactured by Novo Nordisk, was originally approved by the FDA in 2017 for type 2 diabetes management

Despite the growing number of treatment options, insulin therapy is an important part of therapy

The carbonyl of Ser162 of the second protomer receives multiple h-bonds from both the backbone amine and the sidechain of VNAR-D1 Ser27 (Fig

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GLP-1 is an incretin hormone that enhances glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying, improving glycemic control and promoting weight loss