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While little is known about the role of this GLP-1R population, a function of the Brunner's glands is to secrete mucus to lubricate the intestinal wall and, as GLP-1 has been suggested to be a positive regulator of gut-barrier function, GLP-1 may act on these glands to increase mucus secretion, thereby decreasing inflammation and protecting against intestinal damage

The native Lys34 of GLP-1(7-37)-OH appeared highly flexible in complex with the GLP-1R extracellular domain, whereas Arg34 of semaglutide adopted a more defined conformation oriented toward Glu27, as depicted in Figure 4

doi: 10.1002/mco2.69 46 MaCJiangYXiangYLiCXieXZhangYet al

Homogenates were diluted with Tris lysis buffer 1:10 for PSD95 and 1:4 for proinflammatory analysis

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