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IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]

Exclusion criteria included prematurity, being small for gestational age, neurological or psychiatric disorders, ADHD, movement disorders, syndromic short stature, additional pituitary hormone deficiency, known sleep disorder, known medical therapy for a chronic condition, or less than 6 months of growth hormone treatment

Together, they help maintain whats called the fluid balance inside and outside of your cells

1992 doi: 10.3177/jnsv.38.special_1