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Serum superoxide dismutase (SOD) and glutathione (GSH) activities were also significantly increased in all NPs-treated groups compared with the control, indicating an upregulation of enzymatic and non-enzymatic antioxidant mechanisms

Left ventricular hypertrophy is a hallmark of CKD and the main factors underlying its development include insulin resistance, accumulation of endogenous cardiotonic steroids and uraemic toxins, vitamin D deficiency, hyperphosphataemia and haemodynamic overload, which induces mechanical stress

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In its fully oxidized state, CoQ 10 accepts electrons from NADH-ubiquinone reductase (Complex I) and succinate-Q oxidoreductase (Complex II), and transfers them to Complex III