In animal studies, thyroid C-cell tumours have been observed, though the clinical significance in humans remains under investigation
But researchers are increasingly seeing signs that some benefits may be weight-independent
Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]
If this condition is left untreated, gastroparesis could contribute to malnutrition, dehydration, the formation of a bezoar (a solid mass in the stomach), and a host of other medical issues
Evaluation of the pharmacokinetics and safety of AMG 986 tablet and capsule formulations in healthy adult subjects: a phase I, open-label, randomized study