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Importantly, this interaction was disrupted when WIPI2 was mutagenized in the domain for ATG16L binding, suggesting that MYTHO binding happens only when the WIPI2-ATG16L complex is formed

More importantly, they showed reduced markers of apoptosis

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As confirmatory secondary endpoints, the team assessed whether participants attained at least 10%, 15%, and 20% bodyweight reduction till week 68 and reported any physical function outcomes, which included absolute body weight, BMI, waist circumference, blood pressure, glucose homeostasis changes, and glycaemic status

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